![Anti-HTR2A nanobody [SAA1362] (STJN000184)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200797/412979/STJN000184-SDS-PAGE-1__47409.1749232504.jpg?c=1 "Anti-HTR2A nanobody [SAA1362] (STJN000184)")
![Anti-HTR2A nanobody [SAA1362] (STJN000184)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200797/412979/STJN000184-SDS-PAGE-1__47409.1749232504.jpg?c=1 "Anti-HTR2A nanobody [SAA1362] (STJN000184)")
Anti-HTR2A nanobody [SAA1362] (STJN000184)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-5-Hydroxytryptamine Receptor 2a is suitable for use in Immunoprecipitation research applications. |
| Applications | IP |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1362 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | HTR2A |
| Gene ID | 3356 |
| Uniprot ID | 5HT2A_HUMAN |
Additional Info
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. |
| Protein Name | 5-Hydroxytryptamine Receptor 2a5-Ht-25-Ht-2aSerotonin Receptor 2a |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendriteAxonCytoplasmic VesicleMembraneCaveolaPresynapse |
| Alternative Nanobody Names | Anti-5-Hydroxytryptamine Receptor 2a nanobodyAnti-5-Ht-2 nanobodyAnti-5-Ht-2a nanobodyAnti-Serotonin Receptor 2a nanobodyAnti-HTR2A nanobodyAnti-HTR2 nanobody |
Information sourced from Uniprot.org