Anti-HSPH1 antibody (1-100) [S9MR] (STJ11102129)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Hsp105 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S9MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSPH1 |
| Gene ID | 10808 |
| Uniprot ID | HS105_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MSVVGLDVGSQSCYIAVARA GGIETIANEFSDRCTPSVIS FGSKNRTIGVAAKNQQITHA NNTVSNFKRFHGRAFNDPFI QKEKENLSYDLVPLKNGGVG |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HSP105/HSPH1 (Q92598). |
Additional Info
| Tissue Specificity | Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. |
| Post Translational Modifications | Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |
| Function | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. |
| Protein Name | Heat Shock Protein 105 KdaAntigen Ny-Co-25Heat Shock 110 Kda ProteinHeat Shock Protein Family H Member 1 |
| Database Links | Reactome: R-HSA-3000484Reactome: R-HSA-3371453 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Heat Shock Protein 105 Kda antibodyAnti-Antigen Ny-Co-25 antibodyAnti-Heat Shock 110 Kda Protein antibodyAnti-Heat Shock Protein Family H Member 1 antibodyAnti-HSPH1 antibodyAnti-HSP105 antibodyAnti-HSP110 antibodyAnti-KIAA0201 antibody |
Information sourced from Uniprot.org