| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSPA6 (474-643) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSPA6 |
| Gene ID: |
3310 |
| Uniprot ID: |
HSP76_HUMAN |
| Immunogen Region: |
474-643 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 474-643 of human HSPA6 (NP_002146.2). |
| Immunogen Sequence: |
PQIEVTFDIDANGILSVTAT DRSTGKANKITITNDKGRLS KEEVERMVHEAEQYKAEDEA QRDRVAAKNSLEAHVFHVKG SLQEESLRDKIPEEDRRKMQ DKCREVLAWLEHNQLAEKEE YEHQKRELEQICRPIFSRLY GGPGVPGGSSCGTQARQGDP STGPIIEEVD |
| Function | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. |
| Protein Name | Heat Shock 70 Kda Protein 6Heat Shock 70 Kda Protein B' |
| Database Links | Reactome: R-HSA-3371453Reactome: R-HSA-6798695 |
| Alternative Antibody Names | Anti-Heat Shock 70 Kda Protein 6 antibodyAnti-Heat Shock 70 Kda Protein B' antibodyAnti-HSPA6 antibodyAnti-HSP70B' antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
