Anti-HSP90B1 antibody (754-803 aa) (STJ92925)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GRP94 at the amino acid range 754-803
General Information
| Short Description | Rabbit polyclonal anti-Endoplasmin (754-803 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSP90B1 |
| Gene ID | 7184 |
| Uniprot ID | ENPL_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GRP94 at the amino acid range 754-803 |
| Immunogen Region | 754-803 aa |
| Specificity | Endoplasmin Polyclonal Antibody detects endogenous levels of Endoplasmin protein. |
Additional Info
| Function | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion.the translocation process is mediated by the cargo receptor TMED10. |
| Protein Name | Endoplasmin94 Kda Glucose-Regulated ProteinGrp-94Heat Shock Protein 90 Kda Beta Member 1Heat Shock Protein Family C Member 4Tumor Rejection Antigen 1Gp96 Homolog |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-3000480Reactome: R-HSA-381183Reactome: R-HSA-381426Reactome: R-HSA-6785807Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum LumenSarcoplasmic Reticulum LumenMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Endoplasmin antibodyAnti-94 Kda Glucose-Regulated Protein antibodyAnti-Grp-94 antibodyAnti-Heat Shock Protein 90 Kda Beta Member 1 antibodyAnti-Heat Shock Protein Family C Member 4 antibodyAnti-Tumor Rejection Antigen 1 antibodyAnti-Gp96 Homolog antibodyAnti-HSP90B1 antibodyAnti-GRP94 antibodyAnti-HSPC4 antibodyAnti-TRA1 antibody |
Information sourced from Uniprot.org