Anti-Hsp75 antibody [R04-3P9] (STJA0037253)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TRAP1
General Information
| Short Description | Rabbit monoclonal anti-Hsp75 for use in WB, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-3P9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TRAP1 |
| Gene ID | 10131 |
| Uniprot ID | TRAP1_HUMAN |
| Immunogen | A synthesized peptide derived from human TRAP1 |
Additional Info
| Tissue Specificity | Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. |
| Function | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. |
| Protein Name | Heat Shock Protein 75 Kda - MitochondrialHsp 75Heat Shock Protein Family C Member 5Tnfr-Associated Protein 1Tumor Necrosis Factor Type 1 Receptor-Associated ProteinTrap-1 |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembraneMitochondrion Matrix |
| Alternative Antibody Names | Anti-Heat Shock Protein 75 Kda - Mitochondrial antibodyAnti-Hsp 75 antibodyAnti-Heat Shock Protein Family C Member 5 antibodyAnti-Tnfr-Associated Protein 1 antibodyAnti-Tumor Necrosis Factor Type 1 Receptor-Associated Protein antibodyAnti-Trap-1 antibodyAnti-TRAP1 antibodyAnti-HSP75 antibodyAnti-HSPC5 antibody |
Information sourced from Uniprot.org