Anti-Hsp20 antibody [R07-5H8] (STJA0036200)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Hsp20
General Information
| Short Description | Rabbit monoclonal anti-Hsp20 for use in WB, IHC-P and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-5H8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HSPB6 |
| Gene ID | 126393 |
| Uniprot ID | HSPB6_HUMAN |
| Immunogen | A synthesized peptide derived from human Hsp20 |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. Phosphorylated at Ser-16 by PKA and probably PKD1K.required to protect cardiomyocytes from apoptosis. |
| Function | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. |
| Protein Name | Heat Shock Protein Beta-6Hspb6Heat Shock 20 Kda-Like Protein P20Heat Shock Protein Family B Member 6 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusSecretedTranslocates To Nuclear Foci During Heat Shock |
| Alternative Antibody Names | Anti-Heat Shock Protein Beta-6 antibodyAnti-Hspb6 antibodyAnti-Heat Shock 20 Kda-Like Protein P20 antibodyAnti-Heat Shock Protein Family B Member 6 antibodyAnti-HSPB6 antibody |
Information sourced from Uniprot.org