Anti-HSF2BP antibody (201-251 aa) (STJ195935)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human HSF2B at the amino acid range 201-251
General Information
| Short Description | Rabbit polyclonal anti-Heat shock factor 2-binding protein (201-251 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSF2BP |
| Gene ID | 11077 |
| Uniprot ID | HSF2B_HUMAN |
| Immunogen | Synthesized peptide derived from the human HSF2B at the amino acid range 201-251 |
| Immunogen Region | 201-251 aa |
| Specificity | This antibody detects endogenous levels of HSF2B at Human |
Additional Info
| Post Translational Modifications | Sumoylated by UBE2I in response to MEKK1-mediated stimuli. |
| Function | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Required for proper recombinase recruitment in female meiosis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis. |
| Protein Name | Heat Shock Factor 2-Binding Protein |
| Database Links | |
| Cellular Localisation | CytoplasmChromosomeLocalizes On Double-Strand Breaks (Dsbs) In Mitotic And Meiotic Chromosomes |
| Alternative Antibody Names | Anti-Heat Shock Factor 2-Binding Protein antibodyAnti-HSF2BP antibodyAnti-MEILB2 antibody |
Information sourced from Uniprot.org