| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-3R-3-hydroxyacyl-CoA dehydrogenase is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HSD17B8 |
| Gene ID: | 7923 |
| Uniprot ID: | DHB8_HUMAN |
| Specificity: | DHB8 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Required for the solubility and assembly of the heterotetramer 3-ketoacyl-acyl carrier protein (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference.this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol. |
| Protein Name | (3r-3-Hydroxyacyl-Coa Dehydrogenase 17-Beta-Hydroxysteroid Dehydrogenase 8 17-Beta-Hsd 8 Hsd17b8 3-Ketoacyl-Acyl-Carrier-Protein Reductase Alpha Subunit Kar Alpha Subunit 3-Oxoacyl-Acyl-Carrier-Protein Reductase Estradiol 17-Beta-Dehydrogenase 8 Protein Ke6 Ke6 Short Chain Dehydrogenase/Reductase Family 30c Member 1 Testosterone 17-Beta-Dehydrogenase 8 |
| Database Links | Reactome: R-HSA-75105 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-(3r-3-Hydroxyacyl-Coa Dehydrogenase antibody Anti-17-Beta-Hydroxysteroid Dehydrogenase 8 antibody Anti-17-Beta-Hsd 8 antibody Anti-Hsd17b8 antibody Anti-3-Ketoacyl-Acyl-Carrier-Protein Reductase Alpha Subunit antibody Anti-Kar Alpha Subunit antibody Anti-3-Oxoacyl-Acyl-Carrier-Protein Reductase antibody Anti-Estradiol 17-Beta-Dehydrogenase 8 antibody Anti-Protein Ke6 antibody Anti-Ke6 antibody Anti-Short Chain Dehydrogenase/Reductase Family 30c Member 1 antibody Anti-Testosterone 17-Beta-Dehydrogenase 8 antibody Anti-HSD17B8 antibody Anti-FABGL antibody Anti-HKE6 antibody Anti-RING2 antibody Anti-SDR30C1 antibody |
Information sourced from Uniprot.org