| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Very-long-chain 3-oxoacyl-CoA reductase is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSD17B12 |
| Gene ID: |
51144 |
| Uniprot ID: |
DHB12_HUMAN |
| Specificity: |
DHB12 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. |
| Protein Name | Very-Long-Chain 3-Oxoacyl-Coa Reductase17-Beta-Hydroxysteroid Dehydrogenase 1217-Beta-Hsd 123-Ketoacyl-Coa ReductaseKarEstradiol 17-Beta-Dehydrogenase 12Short Chain Dehydrogenase/Reductase Family 12c Member 1 |
| Database Links | Reactome: R-HSA-193048Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Very-Long-Chain 3-Oxoacyl-Coa Reductase antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase 12 antibodyAnti-17-Beta-Hsd 12 antibodyAnti-3-Ketoacyl-Coa Reductase antibodyAnti-Kar antibodyAnti-Estradiol 17-Beta-Dehydrogenase 12 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 12c Member 1 antibodyAnti-HSD17B12 antibodyAnti-SDR12C1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
