| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HSD17B1 |
| Gene ID: | 3292 |
| Uniprot ID: | DHB1_HUMAN |
| Immunogen Region: | 1-328 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2). |
| Immunogen Sequence: | MARTVVLITGCSSGIGLHLA VRLASDPSQSFKVYATLRDL KTQGRLWEAARALACPPGSL ETLQLDVRDSKSVAAARERV TEGRVDVLVCNAGLGLLGPL EALGEDAVASVLDVNVVGTV RMLQAFLPDMKRRGSGRVLV TGSVGGLMGLPFNDVYCASK FALEGLCESLAVLLLPFGVH LSLIECGPVHTAFMEKVLGS PEEVLDRTDIHTFHRFYQYL AHSKQVFREAAQNPEEVAE |
| Function | Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH. |
| Protein Name | 17-Beta-Hydroxysteroid Dehydrogenase Type 117-Beta-Hsd 120 Alpha-Hydroxysteroid Dehydrogenase20-Alpha-HsdE2dhEstradiol 17-Beta-Dehydrogenase 1Placental 17-Beta-Hydroxysteroid DehydrogenaseShort Chain Dehydrogenase/Reductase Family 28c Member 1 |
| Database Links | Reactome: R-HSA-193144Reactome: R-HSA-2453902 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 1 antibodyAnti-17-Beta-Hsd 1 antibodyAnti-20 Alpha-Hydroxysteroid Dehydrogenase antibodyAnti-20-Alpha-Hsd antibodyAnti-E2dh antibodyAnti-Estradiol 17-Beta-Dehydrogenase 1 antibodyAnti-Placental 17-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 28c Member 1 antibodyAnti-HSD17B1 antibodyAnti-E17KSR antibodyAnti-EDH17B1 antibodyAnti-EDH17B2 antibodyAnti-EDHB17 antibodyAnti-SDR28C1 antibody |
Information sourced from Uniprot.org