| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSCB (30-235) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSCB |
| Gene ID: |
150274 |
| Uniprot ID: |
HSC20_HUMAN |
| Immunogen Region: |
30-235 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human HSCB (NP_741999.3). |
| Immunogen Sequence: |
AASQAGSNYPRCWNCGGPWG PGREDRFFCPQCRALQAPDP TRDYFSLMDCNRSFRVDTAK LQHRYQQLQRLVHPDFFSQR SQTEKDFSEKHSTLVNDAYK TLLAPLSRGLYLLKLHGIEI PERTDYEMDRQFLIEIMEIN EKLAEAESEAAMKEIESIVK AKQKEFTDNVSSAFEQDDFE EAKEILTKMRYFSNIEEKIK LKKIPL |
| Tissue Specificity | Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart. |
| Function | Iron-sulfur cluster co-chaperone protein HscB, mitochondrial: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis. Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic: Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT. |
| Protein Name | Iron-Sulfur Cluster Co-Chaperone Protein HscbDnaj Homolog Subfamily C Member 20 Cleaved Into - Iron-Sulfur Cluster Co-Chaperone Protein Hscb - CytoplasmicC-Hsc20 - Iron-Sulfur Cluster Co-Chaperone Protein Hscb - Mitochondrial |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-1362409 |
| Cellular Localisation | Iron-Sulfur Cluster Co-Chaperone Protein HscbCytoplasmic: CytoplasmMitochondrial: Mitochondrion |
| Alternative Antibody Names | Anti-Iron-Sulfur Cluster Co-Chaperone Protein Hscb antibodyAnti-Dnaj Homolog Subfamily C Member 20 Cleaved Into - Iron-Sulfur Cluster Co-Chaperone Protein Hscb - Cytoplasmic antibodyAnti-C-Hsc20 - Iron-Sulfur Cluster Co-Chaperone Protein Hscb - Mitochondrial antibodyAnti-HSCB antibodyAnti-DNAJC20 antibodyAnti-HSC20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
