Anti-HR antibody (200-480) (STJ113899)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HR (200-480) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HR |
| Gene ID | 55806 |
| Uniprot ID | HAIR_HUMAN |
| Immunogen Region | 200-480 |
| Immunogen Sequence | SLGSKGFYYKDPSIPRLAKE PLAAAEPGLFGLNSGGHLQR AGEAERPSLHQRDGEMGAGR QQNPCPLFLGQPDTVPWTSW PACPPGLVHTLGNVWAGPGD GNLGYQLGPPATPRCPSPEP PVTQRGCCSSYPPTKGGGLG PCGKCQEGLEGGASGASEPS EEVNKASGPRACPPSHHTKL KKTWLTRHSEQFECPRGCPE VEERPVARLRALKRAGSPEV QGAMGSPAPKRPPDPFPGT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human HR (NP_005135.2). |
Additional Info
| Tissue Specificity | Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. |
| Function | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. |
| Protein Name | Lysine-Specific Demethylase HairlessHistone H3-Dimethyl-L-Lysine(9 Demethylase Hairless |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase Hairless antibodyAnti-Histone H3-Dimethyl-L-Lysine(9 Demethylase Hairless antibodyAnti-HR antibody |
Information sourced from Uniprot.org