Anti-HOPX antibody (10-90) (STJA0006594)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HOP AA range: 10-90
General Information
| Short Description | Rabbit polyclonal anti-Homeodomain-only protein (10-90) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HOPX |
| Gene ID | 84525 |
| Uniprot ID | HOP_HUMAN |
| Immunogen | Synthesized peptide derived from human HOP AA range: 10-90 |
| Immunogen Region | 10-90 |
| Specificity | This antibody detects endogenous levels of human HOP |
Additional Info
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
| Protein Name | Homeodomain-Only ProteinLung Cancer-Associated Y ProteinNot Expressed In Choriocarcinoma Protein 1Odd Homeobox Protein 1 |
| Database Links | Reactome: R-HSA-9725554 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Homeodomain-Only Protein antibodyAnti-Lung Cancer-Associated Y Protein antibodyAnti-Not Expressed In Choriocarcinoma Protein 1 antibodyAnti-Odd Homeobox Protein 1 antibodyAnti-HOPX antibodyAnti-HOD antibodyAnti-HOP antibodyAnti-LAGY antibodyAnti-NECC1 antibodyAnti-OB1 antibody |
Information sourced from Uniprot.org