| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HOPX (1-73) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HOPX |
| Gene ID: |
84525 |
| Uniprot ID: |
HOP_HUMAN |
| Immunogen Region: |
1-73 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human HOPX (NP_631957.1). |
| Immunogen Sequence: |
MSAETASGPTEDQVEILEYN FNKVDKHPDSTTLCLIAAEA GLSEEETQKWFKQRLAKWRR SEGLPSECRSVTD |
| Tissue Specificity | Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. |
| Protein Name | Homeodomain-Only ProteinLung Cancer-Associated Y ProteinNot Expressed In Choriocarcinoma Protein 1Odd Homeobox Protein 1 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Homeodomain-Only Protein antibodyAnti-Lung Cancer-Associated Y Protein antibodyAnti-Not Expressed In Choriocarcinoma Protein 1 antibodyAnti-Odd Homeobox Protein 1 antibodyAnti-HOPX antibodyAnti-HOD antibodyAnti-HOP antibodyAnti-LAGY antibodyAnti-NECC1 antibodyAnti-OB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
