| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HOOK3 (489-718) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HOOK3 |
| Gene ID: |
84376 |
| Uniprot ID: |
HOOK3_HUMAN |
| Immunogen Region: |
489-718 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 489-718 of human HOOK3 (NP_115786.1). |
| Immunogen Sequence: |
IALLQSLLDDANLRKNELET ENRLVNQRLLEVQSQVEELQ KSLQDQGSKAEDSVLLKKKL EEHLEKLHEANNELQKKRAI IEDLEPRFNNSSLKIEELQE ALRKKEEEMKQMEERYKKYL EKAKSVIRTLDPKQNQGAAP EIQALKNQLQERDRLFHSLE KEYEKTKSQREMEEKYIVSA WYNMGMTLHKKAAEDRLAST GSGQSFLARQRQATSSRRSY PGHVQPATAR |
| Function | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. |
| Protein Name | Protein Hook Homolog 3H-Hook3Hhk3 |
| Cellular Localisation | CytoplasmCytoskeletonGolgi ApparatusEnriched At The Cis-Face Of The Golgi ComplexLocalizes To Microtubule Asters In ProphaseLocalizes To The Manchette In Elongating Spermatids |
| Alternative Antibody Names | Anti-Protein Hook Homolog 3 antibodyAnti-H-Hook3 antibodyAnti-Hhk3 antibodyAnti-HOOK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
