Anti-HNRNPL antibody (61-110 aa) (STJ93568)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human hnRNP L at the amino acid range 61-110
General Information
| Short Description | Rabbit polyclonal anti-Heterogeneous nuclear ribonucleoprotein L (61-110 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HNRNPL |
| Gene ID | 3191 |
| Uniprot ID | HNRPL_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human hnRNP L at the amino acid range 61-110 |
| Immunogen Region | 61-110 aa |
| Specificity | hnRNP L Polyclonal Antibody detects endogenous levels of hnRNP L protein. |
Additional Info
| Function | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. |
| Protein Name | Heterogeneous Nuclear Ribonucleoprotein LHnrnp L |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasThese Granules Are Not Identical With P Bodies Or Stress Granules |
| Alternative Antibody Names | Anti-Heterogeneous Nuclear Ribonucleoprotein L antibodyAnti-Hnrnp L antibodyAnti-HNRNPL antibodyAnti-HNRPL antibodyAnti-P antibodyAnti-OKcl.14 antibody |
Information sourced from Uniprot.org