• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using hnRNP C1/2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HUVEC cells, treated with EGF 200ng/ml 5', using hnRNP C1/2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of 293T cells using hnRNP C1/2 Polyclonal Antibody diluted at 1：500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-HNRNPC antibody (231-280 aa) (STJ93559)

SKU:
STJ93559

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Heterogeneous nuclear ribonucleoproteins C1/C2 (231-280 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HNRNPC
Gene ID: 3183
Uniprot ID: HNRPC_HUMAN
Immunogen Region: 231-280 aa
Specificity: hnRNP C1/2 Polyclonal Antibody detects endogenous levels of hnRNP C1/2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human hnRNP C1/2 at the amino acid range 231-280
Function Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Protein Name Heterogeneous Nuclear Ribonucleoproteins C1/C2
Hnrnp C1/C2
Database Links Reactome: R-HSA-4570464
Reactome: R-HSA-72163
Reactome: R-HSA-72203
Reactome: R-HSA-9013418
Reactome: R-HSA-9013422
Cellular Localisation Nucleus
Component Of Ribonucleosomes
Alternative Antibody Names Anti-Heterogeneous Nuclear Ribonucleoproteins C1/C2 antibody
Anti-Hnrnp C1/C2 antibody
Anti-HNRNPC antibody
Anti-HNRPC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance