Anti-hnRNP E1/PCBP1 antibody (1-100) [S7MR] (STJ11103007)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal hnRNP E1/PCBP1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S7MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCBP1 |
| Gene ID | 5093 |
| Uniprot ID | PCBP1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MDAGVTESGLNVTLTIRLLM HGKEVGSIIGKKGESVKRIR EESGARINISEGNCPERIIT LTGPTNAIFKAFAMIIDKLE EDINSSMTNSTAASRPPVTL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PCBP1 (Q15365). |
Additional Info
| Tissue Specificity | Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. |
| Post Translational Modifications | Phosphorylated.lowers poly(rC)-binding activity. |
| Function | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing. (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. |
| Protein Name | Poly(Rc-Binding Protein 1Alpha-Cp1Heterogeneous Nuclear Ribonucleoprotein E1Hnrnp E1Nucleic Acid-Binding Protein Sub2.3 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | NucleusCytoplasmLoosely Bound In The NucleusMay Shuttle Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Poly(Rc-Binding Protein 1 antibodyAnti-Alpha-Cp1 antibodyAnti-Heterogeneous Nuclear Ribonucleoprotein E1 antibodyAnti-Hnrnp E1 antibodyAnti-Nucleic Acid-Binding Protein Sub2.3 antibodyAnti-PCBP1 antibody |
Information sourced from Uniprot.org