Anti-Hmox1 antibody (1-266) (STJ11105174)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Hmox1 (1-266) antibody for use in WB, IHC-P, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Hmox1 |
| Gene ID | 15368 |
| Uniprot ID | HMOX1_MOUSE |
| Immunogen Region | 1-266 |
| Immunogen Sequence | ERPQPDSMPQDLSEALKEAT KEVHIQAENAEFMKNFQKGQ VSREGFKLVMASLYHIYTAL EEEIERNKQNPVYAPLYFPE ELHRRAALEQDMAFWYGPHW QEIIPCTPATQHYVKRLHEV GRTHPELLVAHAYTRYLGDL SGGQVLKKIAQKAMALPSSG EGLAFFTFPNIDSPTKFKQL YRARMNTLEMTPEVKHRVTE EAKTAFLLNIELFEELQVML TEEHKDQSPSQMASLRQRP |
| Specificity | Recombinant Protein corresponding to a sequence within amino acids 1-266 of mouse Hmox1 (NP_034572.1). |
Additional Info
| Post Translational Modifications | A soluble form arises by proteolytic removal of the membrane anchor. |
| Function | Heme oxygenase 1: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis. Heme oxygenase 1 soluble form: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
| Protein Name | Heme Oxygenase 1Ho-1P32 Protein Cleaved Into - Heme Oxygenase 1 Soluble Form |
| Database Links | Reactome: R-MMU-189483Reactome: -MMU-917937Reactome: -MMU-9609523Reactome: -MMU-9707564Reactome: -MMU-9707587 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Heme Oxygenase 1 antibodyAnti-Ho-1 antibodyAnti-P32 Protein Cleaved Into - Heme Oxygenase 1 Soluble Form antibodyAnti-Hmox1 antibody |
Information sourced from Uniprot.org