| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HO-1 (1-265) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HMOX1 |
| Gene ID: |
3162 |
| Uniprot ID: |
HMOX1_HUMAN |
| Immunogen Region: |
1-265 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human Heme Oxygenase 1 (HO-1/HMOX1) (NP_002124.1). |
| Immunogen Sequence: |
MERPQPDSMPQDLSEALKEA TKEVHTQAENAEFMRNFQKG QVTRDGFKLVMASLYHIYVA LEEEIERNKESPVFAPVYFP EELHRKAALEQDLAFWYGPR WQEVIPYTPAMQRYVKRLHE VGRTEPELLVAHAYTRYLGD LSGGQVLKKIAQKALDLPSS GEGLAFFTFPNIASATKFKQ LYRSRMNSLEMTPAVRQRVI EEAKTAFLLNIQLFEELQEL LTHDTKDQSPSRAPGLRQR |
| Tissue Specificity | Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). |
| Post Translational Modifications | A soluble form arises by proteolytic removal of the membrane anchor. |
| Function | Heme oxygenase 1: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis. Heme oxygenase 1: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. Heme oxygenase 1 soluble form: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
| Protein Name | Heme Oxygenase 1Ho-1 Cleaved Into - Heme Oxygenase 1 Soluble Form |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-6785807Reactome: R-HSA-844456Reactome: R-HSA-917937Reactome: R-HSA-9609523Reactome: R-HSA-9660826Reactome: R-HSA-9707564Reactome: R-HSA-9707587Reactome: R-HSA-9707616Reactome: R-HSA-9818027 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Heme Oxygenase 1 antibodyAnti-Ho-1 Cleaved Into - Heme Oxygenase 1 Soluble Form antibodyAnti-HMOX1 antibodyAnti-HO antibodyAnti-HO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
