Anti-HMHB1 antibody (1-24 aa) (STJ197628)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human HMHB1 at the amino acid range 1-24
General Information
| Short Description | Rabbit polyclonal anti-Minor histocompatibility protein HB-1 (1-24 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMHB1 |
| Gene ID | 57824 |
| Uniprot ID | HMHB1_HUMAN |
| Immunogen | Synthesized peptide derived from the human HMHB1 at the amino acid range 1-24 |
| Immunogen Region | 1-24 aa |
| Specificity | This antibody detects endogenous levels of human HMHB1 |
Additional Info
| Function | Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocomplatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease. |
| Protein Name | Minor Histocompatibility Protein Hb-1 Cleaved Into - Minor Histocompatibility Antigen Hb-1Mhag Hb-1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Minor Histocompatibility Protein Hb-1 Cleaved Into - Minor Histocompatibility Antigen Hb-1 antibodyAnti-Mhag Hb-1 antibodyAnti-HMHB1 antibody |
Information sourced from Uniprot.org