Anti-HMGCS2 antibody [SRM14665] (STJ11109395)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal HMGCS2 antibody for use in WB, IF, ICC, IF-P, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IF-P/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14665 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:2000-1:8000IF/ICC, 1:100-1:400IF-P, 1:100-1:400IHC-P, 1:1000-1:4000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMGCS2 |
| Gene ID | 3158 |
| Uniprot ID | HMCS2_HUMAN |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. Isoform 3: Highest expression detected in heart and skeletal muscle. |
| Post Translational Modifications | Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity. |
| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
| Protein Name | Hydroxymethylglutaryl-Coa Synthase - MitochondrialHmg-Coa Synthase3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-77111Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Synthase - Mitochondrial antibodyAnti-Hmg-Coa Synthase antibodyAnti-3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase antibodyAnti-HMGCS2 antibody |
Information sourced from Uniprot.org