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![Anti-HMB45 antigen antibody [HMB45] (STJ16101748)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152254/347104/STJ16101748_1__54136.1681999369.jpg?c=1 "Anti-HMB45 antigen antibody [HMB45] (STJ16101748)")
Anti-HMB45 antigen antibody [HMB45] (STJ16101748)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenExtract of pigmented melanoma metastases from lymph nodes.
General Information
| Short Description | Mouse monoclonal anti-HMB45 antigen (Melanoma Marker) for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | HMB45 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | >=10.8 mg/L |
| Dilution Range | IHC-P 1:60 |
| Formulation | Tissue culture supernatant with Sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Extract of pigmented melanoma metastases from lymph nodes. |
Additional Info
| Background | The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells. Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation. The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996) ). |
Information sourced from Uniprot.org