Anti-HKDC1 antibody [R06-8I4] (STJA0035224)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human HKDC1
General Information
| Short Description | Rabbit monoclonal anti-HKDC1 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-8I4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HKDC1 |
| Gene ID | 80201 |
| Uniprot ID | HKDC1_HUMAN |
| Immunogen | Recombinant protein of human HKDC1 |
Additional Info
| Tissue Specificity | Widely expressed. Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines.the acinar centrocytes and interlobular ducts of the pancreas.and the alveolar macrophages in the lungs (at protein level). Present at moderate level in the thyroid follicular epithelium (at protein level). |
| Function | Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy.however additional evidences are required to confirm this role. |
| Protein Name | Hexokinase Hkdc1Hexokinase Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | CytoplasmMitochondrion MembranePeripheral Membrane ProteinPhotoreceptor Inner SegmentThe Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrion |
| Alternative Antibody Names | Anti-Hexokinase Hkdc1 antibodyAnti-Hexokinase Domain-Containing Protein 1 antibodyAnti-HKDC1 antibody |
Information sourced from Uniprot.org