| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HKDC1 (150-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HKDC1 |
| Gene ID: |
80201 |
| Uniprot ID: |
HKDC1_HUMAN |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human HKDC1 (NP_079406.3). |
| Immunogen Sequence: |
LGLTFSFPCRQTKLEEGVLL SWTKKFKARGVQDTDVVSRL TKAMRRHKDMDVDILALVND TVGTMMTCAYDDPYCEVGVI IGTGTNACYMEDMSNIDLVE G |
| Tissue Specificity | Widely expressed. Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines.the acinar centrocytes and interlobular ducts of the pancreas.and the alveolar macrophages in the lungs (at protein level). Present at moderate level in the thyroid follicular epithelium (at protein level). |
| Function | Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy.however additional evidences are required to confirm this role. |
| Protein Name | Hexokinase Hkdc1Hexokinase Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | CytoplasmMitochondrion MembranePeripheral Membrane ProteinPhotoreceptor Inner SegmentThe Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrion |
| Alternative Antibody Names | Anti-Hexokinase Hkdc1 antibodyAnti-Hexokinase Domain-Containing Protein 1 antibodyAnti-HKDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
