| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Hemojuvelin (270-350 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HJV |
| Gene ID: |
148738 |
| Uniprot ID: |
RGMC_HUMAN |
| Immunogen Region: |
270-350 aa |
| Specificity: |
RGMC Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Post Translational Modifications | Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis. |
| Function | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. |
| Protein Name | HemojuvelinHemochromatosis Type 2 ProteinHemojuvelin Bmp CoreceptorRgm Domain Family Member C |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorAlso Released In The Extracellular Space |
| Alternative Antibody Names | Anti-Hemojuvelin antibodyAnti-Hemochromatosis Type 2 Protein antibodyAnti-Hemojuvelin Bmp Coreceptor antibodyAnti-Rgm Domain Family Member C antibodyAnti-HJV antibodyAnti-HFE2 antibodyAnti-RGMC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
