| Host: | Mouse |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Histone H3 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | SM0412 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB (H, M, R) 1:500-1:1000IHC/IF (H, M, R) 1:500-1:1000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | H3-3A.H3-3B |
| Gene ID: | 3020/3021 |
| Uniprot ID: | H33_HUMAN |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Histone H3 |
| Function | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Protein Name | Histone H3.3 |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-201722Reactome: R-HSA-212300Reactome: R-HSA-2299718Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-427359Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-5334118Reactome: R-HSA-5578749Reactome: R-HSA-5617472Reactome: R-HSA-5625886Reactome: R-HSA-68616Reactome: R-HSA-73728Reactome: R-HSA-73772Reactome: R-HSA-8936459Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-912446Reactome: R-HSA-9616222Reactome: R-HSA-9670095Reactome: R-HSA-9710421Reactome: R-HSA-977225Reactome: R-HSA-9821002Reactome: R-HSA-9821993Reactome: R-HSA-983231Reactome: R-HSA-9843940Reactome: R-HSA-9843970Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone H3.3 antibodyAnti-H3-3A antibodyAnti-H3.3A antibodyAnti-H3F3 antibodyAnti-H3F3A antibodyAnti-PP781.H3-3B antibodyAnti-H3.3B antibodyAnti-H3F3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
