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Anti-Histone H1 antibody [AE-4] (STJ16100269)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenA BALB/c mouse was immunized with human leukemia biopsy cells. Fusion partner: NS-1.
General Information
| Short Description | Mouse monoclonal anti-Histone H1 for use in FC, IF and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AE-4 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | Flow Cytometry (1-2 µg/million cells in 0.1ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunofluorescence (0.5-1 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; staining of formal |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8°C upon receipt. |
Target Information
| Gene Symbol | H1-0 |
| Gene ID | 3005 |
| Uniprot ID | H10_HUMAN |
| Immunogen | A BALB/c mouse was immunized with human leukemia biopsy cells. Fusion partner: NS-1. |
Additional Info
| Post Translational Modifications | Phosphorylated on Ser-17 in RNA edited version. ADP-ribosylated on Ser-104 in response to DNA damage. |
| Function | Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division. |
| Protein Name | Histone H1.0Histone H1'Histone H1(0 Cleaved Into - Histone H1.0 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-140342Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusChromosomeThe Rna Edited Version Has Been Localized To Nuclear SpecklesDuring MitosisIt Appears In The Vicinity Of Condensed Chromosomes |
| Alternative Antibody Names | Anti-Histone H1.0 antibodyAnti-Histone H1' antibodyAnti-Histone H1(0 Cleaved Into - Histone H1.0 - N-Terminally Processed antibodyAnti-H1-0 antibodyAnti-H1F0 antibodyAnti-H1FV antibody |
Information sourced from Uniprot.org