| Host: | Goat |
| Applications: | Pep-ELISA/IHC/IF/FC |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Histamine Receptor H1 (C-Term) is suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000. IHC: This product has been successfully used in IHC on Rat (PMID: 30226827). Immunofluorescence: This product has been successfully used in IF on Rat (PMID: 30413645 a |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | HRH1 |
| Gene ID: | 3269 |
| Uniprot ID: | HRH1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1 |
| Specificity: | Variants (NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1) encode the same protein. |
| Immunogen Sequence: | CNENFKKTFKRILH |
| Function | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter. Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions. |
| Protein Name | Histamine H1 Receptor H1-R H1r Hh1r |
| Database Links | Reactome: R-HSA-390650 Reactome: R-HSA-416476 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Histamine H1 Receptor antibody Anti-H1-R antibody Anti-H1r antibody Anti-Hh1r antibody Anti-HRH1 antibody |
Information sourced from Uniprot.org