Anti-HIRA antibody [R01-4Z5] (STJA0037337)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human HIRA
General Information
| Short Description | Rabbit monoclonal anti-HIRA for use in WB, ICC, IF, IP and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-4Z5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:50FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HIRA |
| Gene ID | 7290 |
| Uniprot ID | HIRA_HUMAN |
| Immunogen | A synthesized peptide derived from human HIRA |
Additional Info
| Tissue Specificity | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
| Post Translational Modifications | Sumoylated. Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo. |
| Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
| Protein Name | Protein HiraTup1-Like Enhancer Of Split Protein 1 |
| Database Links | Reactome: R-HSA-2559584Reactome: R-HSA-9821993 |
| Cellular Localisation | NucleusPml BodyPrimarilyThough Not ExclusivelyLocalized To The NucleusLocalizes To Pml Bodies Immediately Prior To Onset Of Senescence |
| Alternative Antibody Names | Anti-Protein Hira antibodyAnti-Tup1-Like Enhancer Of Split Protein 1 antibodyAnti-HIRA antibodyAnti-DGCR1 antibodyAnti-HIR antibodyAnti-TUPLE1 antibody |
Information sourced from Uniprot.org