| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-HIPPI (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
IFT57 |
| Gene ID: |
55081 |
| Uniprot ID: |
IFT57_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_060480.1 |
| Immunogen Sequence: |
EQPQEYDDPNATISN |
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.however the relevance of such function remains unclear. |
| Protein Name | Intraflagellar Transport Protein 57 HomologDermal Papilla-Derived Protein 8Estrogen-Related Receptor Beta-Like Protein 1Hip1-Interacting ProteinMhs4r2 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyConcentrates Within The Inner Segment Of Cilia |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 57 Homolog antibodyAnti-Dermal Papilla-Derived Protein 8 antibodyAnti-Estrogen-Related Receptor Beta-Like Protein 1 antibodyAnti-Hip1-Interacting Protein antibodyAnti-Mhs4r2 antibodyAnti-IFT57 antibodyAnti-DERP8 antibodyAnti-ESRRBL1 antibodyAnti-HIPPI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
