Anti-HIPPI antibody (Internal) (STJ71890)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-HIPPI (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 49kDa band observed in Human and Mouse Brain lysates (calculated MW of 49.1kDa according to Human NP_060480.1 and of 48.8kDa according to Mouse NP_082956.2). Recommended concentr |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | IFT57 |
| Gene ID | 55081 |
| Uniprot ID | IFT57_HUMAN |
| Accession Number | NP_060480.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | EQPQEYDDPNATISN |
Additional Info
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.however the relevance of such function remains unclear. |
| Protein Name | Intraflagellar Transport Protein 57 HomologDermal Papilla-Derived Protein 8Estrogen-Related Receptor Beta-Like Protein 1Hip1-Interacting ProteinMhs4r2 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyConcentrates Within The Inner Segment Of Cilia |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 57 Homolog antibodyAnti-Dermal Papilla-Derived Protein 8 antibodyAnti-Estrogen-Related Receptor Beta-Like Protein 1 antibodyAnti-Hip1-Interacting Protein antibodyAnti-Mhs4r2 antibodyAnti-IFT57 antibodyAnti-DERP8 antibodyAnti-ESRRBL1 antibodyAnti-HIPPI antibody |
Information sourced from Uniprot.org