Anti-HIPK3 antibody (860-910) (STJ501346)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino aci region 860-910 on human Homeodomain-interacting protein kinase 3 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-HIPK3 (860-910) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:2, 500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | HIPK3 |
| Gene ID | 10114 |
| Uniprot ID | HIPK3_HUMAN |
| Immunogen | Synthetic peptide taken within amino aci region 860-910 on human Homeodomain-interacting protein kinase 3 protein. |
| Immunogen Region | 860-910 |
Additional Info
| Tissue Specificity | Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung. |
| Post Translational Modifications | Autophosphorylated, but autophosphorylation is not required for catalytic activity. May be sumoylated. |
| Function | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
| Protein Name | Homeodomain-Interacting Protein Kinase 3Androgen Receptor-Interacting Nuclear Protein KinaseAnpkFas-Interacting Serine/Threonine-Protein KinaseFistHomolog Of Protein Kinase Yak1 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Homeodomain-Interacting Protein Kinase 3 antibodyAnti-Androgen Receptor-Interacting Nuclear Protein Kinase antibodyAnti-Anpk antibodyAnti-Fas-Interacting Serine/Threonine-Protein Kinase antibodyAnti-Fist antibodyAnti-Homolog Of Protein Kinase Yak1 antibodyAnti-HIPK3 antibodyAnti-DYRK6 antibodyAnti-FIST3 antibodyAnti-PKY antibody |
Information sourced from Uniprot.org