Anti-HIPK3 antibody (770-850 aa) (STJ191808)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 770-850
General Information
| Short Description | Rabbit polyclonal anti-Homeodomain-interacting protein kinase 3 (770-850 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HIPK3 |
| Gene ID | 10114 |
| Uniprot ID | HIPK3_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 770-850 |
| Immunogen Region | 770-850 aa |
| Specificity | HIPK3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated, but autophosphorylation is not required for catalytic activity. May be sumoylated. |
| Function | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
| Protein Name | Homeodomain-Interacting Protein Kinase 3Androgen Receptor-Interacting Nuclear Protein KinaseAnpkFas-Interacting Serine/Threonine-Protein KinaseFistHomolog Of Protein Kinase Yak1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Homeodomain-Interacting Protein Kinase 3 antibodyAnti-Androgen Receptor-Interacting Nuclear Protein Kinase antibodyAnti-Anpk antibodyAnti-Fas-Interacting Serine/Threonine-Protein Kinase antibodyAnti-Fist antibodyAnti-Homolog Of Protein Kinase Yak1 antibodyAnti-HIPK3 antibodyAnti-DYRK6 antibodyAnti-FIST3 antibodyAnti-PKY antibody |
Information sourced from Uniprot.org