Anti-HIP14/ZDHHC17 antibody (C-Term) (STJ70643)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-HIP14/ZDHHC17 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 70kDa band observed in Mouse Brain lysates (calculated MW of 72.7kDa according to NP_056151.1). Recommended concentration: 1-3µg/ml.IHC: Paraffin embedded Human Testis. Reco |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC17 |
| Gene ID | 23390 |
| Uniprot ID | ZDH17_HUMAN |
| Accession Number | NP_056151.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | CYDQISGSGYQLV |
Additional Info
| Post Translational Modifications | Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3. Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation. |
| Protein Name | Palmitoyltransferase Zdhhc17Acyltransferase Zdhhc17Dhhc Domain-Containing Cysteine-Rich Protein 17Dhhc17Huntingtin Yeast Partner HHuntingtin-Interacting Protein 14Hip-14Huntingtin-Interacting Protein 3Hip-3Huntingtin-Interacting Protein HPutative Mapk-Activating Protein Pm11Putative Nf-Kappa-B-Activating Protein 205Zinc Finger Dhhc Domain-Containing Protein 17 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembranePresynaptic Cell MembraneLow Extracellular Mg(2+) Induces Increase In Golgi And In Post-Golgi Membrane Vesicles |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc17 antibodyAnti-Acyltransferase Zdhhc17 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 17 antibodyAnti-Dhhc17 antibodyAnti-Huntingtin Yeast Partner H antibodyAnti-Huntingtin-Interacting Protein 14 antibodyAnti-Hip-14 antibodyAnti-Huntingtin-Interacting Protein 3 antibodyAnti-Hip-3 antibodyAnti-Huntingtin-Interacting Protein H antibodyAnti-Putative Mapk-Activating Protein Pm11 antibodyAnti-Putative Nf-Kappa-B-Activating Protein 205 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 17 antibodyAnti-ZDHHC17 antibodyAnti-HIP14 antibodyAnti-HIP3 antibodyAnti-HYPH antibodyAnti-KIAA0946 antibodyAnti-HSPC294 antibody |
Information sourced from Uniprot.org