Anti-HIF Prolyl Hydroxylases antibody [R06-1B0] (STJA0035218)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human HIF Prolyl Hydroxylases
General Information
| Short Description | Rabbit monoclonal anti-HIF Prolyl Hydroxylases for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-1B0 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | P4HTM |
| Gene ID | 54681 |
| Uniprot ID | P4HTM_HUMAN |
| Immunogen | A synthetic peptide of human HIF Prolyl Hydroxylases |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. |
| Post Translational Modifications | Glycosylated. |
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Protein Name | Transmembrane Prolyl 4-HydroxylaseP4h-TmHypoxia-Inducible Factor Prolyl Hydroxylase 4Hif-Ph4Hif-Prolyl Hydroxylase 4Hph-4 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Prolyl 4-Hydroxylase antibodyAnti-P4h-Tm antibodyAnti-Hypoxia-Inducible Factor Prolyl Hydroxylase 4 antibodyAnti-Hif-Ph4 antibodyAnti-Hif-Prolyl Hydroxylase 4 antibodyAnti-Hph-4 antibodyAnti-P4HTM antibodyAnti-PH4 antibody |
Information sourced from Uniprot.org