Anti-hGAL antibody [IHC598] (STJA0042187)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
General Information
| Short Description | Mouse monoclonal anti-hGAL for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC598 |
| Conjugation | Unconjugated |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Gene Symbol | GCSAM |
| Gene ID | 257144 |
| Uniprot ID | GCSAM_HUMAN |
| Specificity | Tested and validated on tonsil, lymph node tissue. |
Additional Info
| Tissue Specificity | Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. |
| Post Translational Modifications | Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. |
| Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
| Protein Name | Germinal Center-Associated Signaling And Motility ProteinGerminal Center B-Cell-Expressed Transcript 2 ProteinGerminal Center-Associated Lymphoma ProteinHgal |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneIt Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6 |
| Alternative Antibody Names | Anti-Germinal Center-Associated Signaling And Motility Protein antibodyAnti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibodyAnti-Germinal Center-Associated Lymphoma Protein antibodyAnti-Hgal antibodyAnti-GCSAM antibodyAnti-GAL antibodyAnti-GCET2 antibody |
Information sourced from Uniprot.org