Anti-Hexokinase 1/2 antibody (1-917aa) [1A7] (STJA0041497)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human Hexokinase 2 (1-917aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Hexokinase 1/2 (1-917aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1A7 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HK2 |
| Gene ID | 3099 |
| Uniprot ID | HXK2_HUMAN |
| Accession Number | NP_000180 |
| Immunogen | Recombinant human Hexokinase 2 (1-917aa) purified from E. coli |
| Immunogen Region | 1-917aa |
Additional Info
| Tissue Specificity | Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. |
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. |
| Protein Name | Hexokinase-2Hexokinase Type IiHk IiHexokinase-BMuscle Form Hexokinase |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Mitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmCytosolThe Mitochondrial-Binding Peptide (Mbp) Region Promotes Association With The Mitochondrial Outer MembraneThe Interaction With The Mitochondrial Outer Membrane Via The Mitochondrial-Binding Peptide (Mbp) Region Promotes Higher Stability Of The ProteinRelease From The Mitochondrial Outer Membrane Into The Cytosol Induces Permeability Transition Pore (Ptp) Opening And Apoptosis |
| Alternative Antibody Names | Anti-Hexokinase-2 antibodyAnti-Hexokinase Type Ii antibodyAnti-Hk Ii antibodyAnti-Hexokinase-B antibodyAnti-Muscle Form Hexokinase antibodyAnti-HK2 antibody |
Information sourced from Uniprot.org