Anti-HEXIM1 antibody [SRM14734] (STJ11109464)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal HEXIM1 antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14734 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:500-1:1000IHC-P, 1:50-1:200IF/ICC, 1:50-1:200IP, 0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your s |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEXIM1 |
| Gene ID | 10614 |
| Uniprot ID | HEXI1_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
| Alternative Antibody Names | Anti-Protein Hexim1 antibodyAnti-Cardiac Lineage Protein 1 antibodyAnti-Estrogen Down-Regulated Gene 1 Protein antibodyAnti-Hexamethylene Bis-Acetamide-Inducible Protein 1 antibodyAnti-Menage A Quatre Protein 1 antibodyAnti-HEXIM1 antibodyAnti-CLP1 antibodyAnti-EDG1 antibodyAnti-HIS1 antibodyAnti-MAQ1 antibody |
Information sourced from Uniprot.org