| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein HEXIM1 (181-230 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HEXIM1 |
| Gene ID: | 10614 |
| Uniprot ID: | HEXI1_HUMAN |
| Immunogen Region: | 181-230 aa |
| Specificity: | Hexim1 Polyclonal Antibody detects endogenous levels of Hexim1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HEXIM1 at the amino acid range 181-230 |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1 Cardiac Lineage Protein 1 Estrogen Down-Regulated Gene 1 Protein Hexamethylene Bis-Acetamide-Inducible Protein 1 Menage A Quatre Protein 1 |
| Cellular Localisation | Nucleus Cytoplasm Binds Alpha-Importin And Is Mostly Nuclear |
| Alternative Antibody Names | Anti-Protein Hexim1 antibody Anti-Cardiac Lineage Protein 1 antibody Anti-Estrogen Down-Regulated Gene 1 Protein antibody Anti-Hexamethylene Bis-Acetamide-Inducible Protein 1 antibody Anti-Menage A Quatre Protein 1 antibody Anti-HEXIM1 antibody Anti-CLP1 antibody Anti-EDG1 antibody Anti-HIS1 antibody Anti-MAQ1 antibody |
Information sourced from Uniprot.org