Anti-HEXA antibody (270-529) (STJ27613)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HEXA (270-529) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEXA |
| Gene ID | 3073 |
| Uniprot ID | HEXA_HUMAN |
| Immunogen Region | 270-529 |
| Immunogen Sequence | IPGLLTPCYSGSEPSGTFGP VNPSLNNTYEFMSTFFLEVS SVFPDFYLHLGGDEVDFTCW KSNPEIQDFMRKKGFGEDFK QLESFYIQTLLDIVSSYGKG YVVWQEVFDNKVKIQPDTII QVWREDIPVNYMKELELVTK AGFRALLSAPWYLNRISYGP DWKDFYIVEPLAFEGTPEQK ALVIGGEACMWGEYVDNTNL VPRLWPRAGAVAERLWSNKL TSDLTFAYERLSHFRCELL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2). |
Additional Info
| Post Translational Modifications | N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2) (Probable). N-linked glycan at Asn-157 consists of either GlcNAc or GlcNAc(2)-Man(7-9). N-linked glycan at Asn-295 consists of either GlcNAc, GlcNAc-Fuc, or GlcNAc(2)-Man(4) (Probable). |
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. |
| Protein Name | Beta-Hexosaminidase Subunit AlphaBeta-N-Acetylhexosaminidase Subunit AlphaHexosaminidase Subunit AN-Acetyl-Beta-Glucosaminidase Subunit Alpha |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-3656234Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Beta-Hexosaminidase Subunit Alpha antibodyAnti-Beta-N-Acetylhexosaminidase Subunit Alpha antibodyAnti-Hexosaminidase Subunit A antibodyAnti-N-Acetyl-Beta-Glucosaminidase Subunit Alpha antibodyAnti-HEXA antibody |
Information sourced from Uniprot.org