Anti-HES1 antibody [R01-6B1] (STJA0036013)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Hes1
General Information
| Short Description | Rabbit monoclonal anti-HES1 for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-6B1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HES1 |
| Gene ID | 3280 |
| Uniprot ID | HES1_HUMAN |
| Immunogen | A synthesized peptide derived from human Hes1 |
Additional Info
| Post Translational Modifications | (Microbial infection) Ubiquitinated via human cytomegalovirus/HCMV protein IE1 that assembles a HES1 ubiquitination complex.leading to HES1 proteasomal degradation. |
| Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. |
| Protein Name | Transcription Factor Hes-1Class B Basic Helix-Loop-Helix Protein 39Bhlhb39Hairy And Enhancer Of Split 1Hairy HomologHairy-Like ProteinHhl |
| Database Links | Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-8940973Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Hes-1 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 39 antibodyAnti-Bhlhb39 antibodyAnti-Hairy And Enhancer Of Split 1 antibodyAnti-Hairy Homolog antibodyAnti-Hairy-Like Protein antibodyAnti-Hhl antibodyAnti-HES1 antibodyAnti-BHLHB39 antibodyAnti-HL antibodyAnti-HRY antibody |
Information sourced from Uniprot.org