Anti-HEPH antibody (STJA0007864)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Hephaestin
General Information
| Short Description | Rabbit polyclonal anti-Hephaestin for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEPH |
| Gene ID | 9843 |
| Uniprot ID | HEPH_HUMAN |
| Immunogen | Synthesized peptide derived from human Hephaestin |
| Specificity | This antibody detects endogenous levels of Hephaestin at Human, Mouse, Rat |
Additional Info
| Function | Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body. |
| Protein Name | HephaestinHp |
| Database Links | Reactome: R-HSA-425410Reactome: R-HSA-5655799Reactome: R-HSA-917937 |
| Cellular Localisation | Basolateral Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hephaestin antibodyAnti-Hp antibodyAnti-HEPH antibodyAnti-KIAA0698 antibodyAnti-UNQ2562 antibodyAnti-PRO6242 antibody |
Information sourced from Uniprot.org