Anti-HECW1 antibody (1-67 aa) (STJ190783)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein at the amino acid range 1-67
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase HECW1 (1-67 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HECW1 |
| Gene ID | 23072 |
| Uniprot ID | HECW1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein at the amino acid range 1-67 |
| Immunogen Region | 1-67 aa |
| Specificity | HECW1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hecw1Hect - C2 And Ww Domain-Containing Protein 1Hect-Type E3 Ubiquitin Transferase Hecw1Nedd4-Like E3 Ubiquitin-Protein Ligase 1Hnedl1 |
| Database Links | Reactome: R-HSA-4641258 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hecw1 antibodyAnti-Hect - C2 And Ww Domain-Containing Protein 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hecw1 antibodyAnti-Nedd4-Like E3 Ubiquitin-Protein Ligase 1 antibodyAnti-Hnedl1 antibodyAnti-HECW1 antibodyAnti-KIAA0322 antibodyAnti-NEDL1 antibody |
Information sourced from Uniprot.org