Anti-HECTD1 antibody (2518-2610) (STJ116358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HECTD1 (2518-2610) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HECTD1 |
| Gene ID | 25831 |
| Uniprot ID | HECD1_HUMAN |
| Immunogen Region | 2518-2610 |
| Immunogen Sequence | PGFLRFVRVLCGMSSDERKA FLQFTTGCSTLPPGGLANLH PRLTVVRKVDATDASYPSVN TCVHYLKLPEYSSEEIMRER LLAATMEKGFHLN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 2518-2610 of human HECTD1 (NP_056197.3). |
Additional Info
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hectd1E3 Ligase For Inhibin ReceptorEulirHect Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hectd1 antibodyAnti-E3 Ligase For Inhibin Receptor antibodyAnti-Eulir antibodyAnti-Hect Domain-Containing Protein 1 antibodyAnti-HECTD1 antibodyAnti-KIAA1131 antibody |
Information sourced from Uniprot.org