Anti-HDGFRP2 antibody (501-670) (STJ29620)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HDGFRP2 (501-670) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HDGFL2 |
| Gene ID | 84717 |
| Uniprot ID | HDGR2_HUMAN |
| Immunogen Region | 501-670 |
| Immunogen Sequence | EELGTLQVTSQILQKNTDVV ATLKKIRRYKANKDVMEKAA EVYTRLKSRVLGPKIEAVQK VNKAGMEKEKAEEKLAGEEL AGEEAPQEKAEDKPSTDLSA PVNGEATSQKGESAEDKEHE EGRDSEEGPRCGSSEDLHDV REGPDLDRPGSDRQERERAR GDSEALDEES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 501-670 of human HDGFRP2 (NP_116020.1). |
Additional Info
| Tissue Specificity | Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples. |
| Function | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression. |
| Protein Name | Hepatoma-Derived Growth Factor-Related Protein 2Hdgf-Related Protein 2Hrp-2Hepatoma-Derived Growth Factor 2Hdgf-2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Hepatoma-Derived Growth Factor-Related Protein 2 antibodyAnti-Hdgf-Related Protein 2 antibodyAnti-Hrp-2 antibodyAnti-Hepatoma-Derived Growth Factor 2 antibodyAnti-Hdgf-2 antibodyAnti-HDGFL2 antibodyAnti-HDGF2 antibodyAnti-HDGFRP2 antibodyAnti-HRP2 antibodyAnti-UNQ785 antibodyAnti-PRO1604 antibody |
Information sourced from Uniprot.org