Anti-HDGF antibody (1-240) (STJ115610)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HDGF (1-240) antibody for use in WB, IHC-P, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HDGF |
| Gene ID | 3068 |
| Uniprot ID | HDGF_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MSRSNRQKEYKCGDLVFAKM KGYPHWPARIDEMPEAAVKS TANKYQVFFFGTHETAFLGP KDLFPYEESKEKFGKPNKRK GFSEGLWEIENNPTVKASGY QSSQKKSCVEEPEPEPEAAE GDGDKKGNAEGSSDEEGKLV IDEPAKEKNEKGALKRRAGD LLEDSPKRPKEAENPEGEEK EAATLEVERPLPMEVEKNST PSEPGSGRGPPQEEEEEEDE EEEATKEDAEAPGIRDHES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HDGF (NP_004485.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. Phosphorylation at Ser-165 is likely to be required for secretion. |
| Function | Isoform 1: Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein. Isoform 2: Does not have mitogenic activity for fibroblasts. Does not bind heparin. Isoform 3: Has mitogenic activity for fibroblasts. Heparin-binding protein. |
| Protein Name | Hepatoma-Derived Growth FactorHdgfHigh Mobility Group Protein 1-Like 2Hmg-1l2 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmSecretedExtracellular ExosomeSecreted By Exosomes And Is Located Inside The ExosomeMay Also Be Secreted As Free Protein Via An As Yet Unknown PathwayIsoform 2: NucleusSecreted By Exosomes And Is Located On The Outer Exosome SurfaceIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Hepatoma-Derived Growth Factor antibodyAnti-Hdgf antibodyAnti-High Mobility Group Protein 1-Like 2 antibodyAnti-Hmg-1l2 antibodyAnti-HDGF antibodyAnti-HMG1L2 antibody |
Information sourced from Uniprot.org