Anti-HDAC11 antibody (1-347 aa) [SRM5226] (STJ11107108)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal HDAC11 (1-347 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5226 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HDAC11 |
| Gene ID | 79885 |
| Uniprot ID | HDA11_HUMAN |
| Immunogen Region | 1-347 aa |
| Immunogen Sequence | MLHTTQLYQHVPETRWPIVY SPRYNITFMGLEKLHPFDAG KWGKVINFLKEEKLLSDSML VEAREASEEDLLVVHTRRYL NELKWSFAVATITEIPPVIF LPNFLVQRKVLRPLRTQTGG TIMAGKLAVERGWAINVGGG FHHCSSDRGGGFCAYADITL AIKFLFERVEGISRATIIDL DAHQGNGHERDFMDDKRVYI MDVYNRHIYPGDRFAKQAIR RKVELEWGTEDDEYLDKVE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-347 of human HDAC11 (NP_079103.2). |
Additional Info
| Tissue Specificity | Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
| Protein Name | Histone Deacetylase 11Hd11 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone Deacetylase 11 antibodyAnti-Hd11 antibodyAnti-HDAC11 antibody |
Information sourced from Uniprot.org