Anti-HCRT antibody (21-70 aa) (STJ192585)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 21-70
General Information
| Short Description | Rabbit polyclonal anti-Hypocretin neuropeptide precursor (21-70 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HCRT |
| Gene ID | 3060 |
| Uniprot ID | OREX_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 21-70 |
| Immunogen Region | 21-70 aa |
| Specificity | OREX Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. |
| Protein Name | Hypocretin Neuropeptide PrecursorHypocretinHcrtOrexin PrecursorPrepro-OrexinPreprohypocretin Cleaved Into - Orexin-AHypocretin-1Hcrt1 - Orexin-BHypocretin-2Hcrt2 |
| Database Links | Reactome: R-HSA-389397Reactome: R-HSA-416476 |
| Cellular Localisation | Rough Endoplasmic ReticulumCytoplasmic VesicleSynapseAssociated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses |
| Alternative Antibody Names | Anti-Hypocretin Neuropeptide Precursor antibodyAnti-Hypocretin antibodyAnti-Hcrt antibodyAnti-Orexin Precursor antibodyAnti-Prepro-Orexin antibodyAnti-Preprohypocretin Cleaved Into - Orexin-A antibodyAnti-Hypocretin-1 antibodyAnti-Hcrt1 - Orexin-B antibodyAnti-Hypocretin-2 antibodyAnti-Hcrt2 antibodyAnti-HCRT antibodyAnti-OX antibodyAnti-PPORX antibodyAnti-PPOX antibody |
Information sourced from Uniprot.org