Anti-HCN4 antibody (C-Term) (STJ13101758)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-HCN4 (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | HCN4 |
| Gene ID | 10021 |
| Uniprot ID | HCN4_HUMAN |
| Immunogen | A synthetic peptide from c-terminal region of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for HCN4. |
Additional Info
| Post Translational Modifications | S-palmitoylated. |
| Function | Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (Probable). Contributes to the native pacemaker currents in neurons (Ih) (Probable). May mediate responses to sour stimuli. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 antibodyAnti-HCN4 antibody |
Information sourced from Uniprot.org