| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HCN2 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:2000 is recommended for IHC and 1:500 for WB. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Hcn2 |
| Gene ID: |
15166 |
| Uniprot ID: |
HCN2_MOUSE |
| Specificity: |
Specific for HCN2. |
| Immunogen: |
A synthetic peptide from mouse HCN2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat. |
| Post Translational Modifications | S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2. Phosphorylation at Ser-641 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. |
| Function | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2Brain Cyclic Nucleotide-Gated Channel 2Bcng-2Hyperpolarization-Activated Cation Channel 1Hac-1 |
| Database Links | Reactome: R-MMU-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Brain Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Bcng-2 antibodyAnti-Hyperpolarization-Activated Cation Channel 1 antibodyAnti-Hac-1 antibodyAnti-Hcn2 antibodyAnti-Bcng2 antibodyAnti-Hac1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
